Activité biologique des produits naturels: Nos publications scientifiques

Notre Laboratoire d'Analyse de l'Activité Biologique des Produits Naturels a participé en étroite collaboration avec le Laboratoire LASEVE
à la publication de plus d'une vingtaine d'articles depuis 2003, dans des périodiques scientifiques révisés par les pairs:
Ces périodiques sont indexés et disponibles par l'entremise de banques de données scientifiques telles que:

PubMed ScienceDirect WileyInterScience American Chemical Society

Plusieurs de nos références bibliographiques seront accompagnées d'un lien vers l'une ou plusieurs de ces banques de données.
En cliquant sur l'un ou l'autre de ces liens représentés par des icones, vous pourrez lire le résumé de chaque article.
Quelques uns sont libres d'accès (gratuits) et afficheront un lien direct vers le texte intégral en fichier pdf.

Vous ne voulez rien manquer des prochaines publications scientifiques du Laboratoire LASEVE?!
Presque toutes nos publications scientifiques passent sur Pubmed ou ScienceDirect;
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Liste des publications*

*Vous en cherchez une en particulier? Utilisez la fonction de recherche de votre navigateur avec le racourci clavier Ctrl+F.

Journal of Essential Oil Research, Volume 22, Issue 2, Pages 164-169, Published Mar-Apr 2010.
Aromas From Quebec. II. Composition of the Essential Oil of the Rhizomes and Roots of Asarum canadense L.
André Belanger, Guy Collin, François-Xavier Garneau, Hélène Gagnon, André Pichette

Canadian Journal of Chemistry, Volume 88, Issue 2, Pages 104-110, 2010.
Cytotoxic phenolic compounds in leaf buds of Populus tremuloides
André Pichette, Azadeh Eftekhari, Patricia Georges, Serge Lavoie, Vakhtang Mshvildadze, and Jean Legault

Chemistry of Natural Compounds, Volume 45, Issue 3, Pages 455-456, Published May 2009.
Aurone from Astragalus microcephalus stems
MD Alaniya, NS Kavtaradze, Serge Lavoie, André Pichette, VD Mshvildadze

Bioorganic and Medicinal Chemistry, Article in Press SD
In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr
Rostand M. Ngoumfo, Jean-Bosco Jouda, Ferdinand T. Mouafo, Justin Komguem, Céline D. Mbazoa, Tze Chieh Shiao, Mohammed I. Choudhary, Hartmut Laatsch, Jean Legault, André Pichette and René Roy

Journal of Medicinal Food, Volume 13 No(2), Pages 1-9, 2010.PM
Antioxidant activity, inhibition of NO production and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum
Jean Legault, Karl Girard-Lalancette, Carole Grenon, Catherine Dussault, André Pichette
Traduction du résumé de cet article

Synthetic Communications, Volume 40, Issue 2, Pages 213-221, 2010.
Acid-Catalyzed E-Ring Expansion and Isomerization of 3-Acetylbetulin: Synthesis of Cytotoxic Anhydrobetulin Saponins
Dominic Thibeault, Jean Legault, Charles Gauthier, Serge Lavoie, Jimmy Bouchard, André Pichette

Food Chemistry, Volume 115, Issue 2, Pages 720-726, 2009 SD
Sensitive Cell-Based Assay using DCFH Oxidation for the Determination of Pro- and Antioxidant Properties of Compounds and Mixtures : Analysis of Fruit and Vegetable Juices
Karl Girard-Lalancette, André Pichette, Jean Legault
Traduction du résumé de cet article

Soil and Water Management and Conservation, Volume 73, Pages 780-791, 2009.
Efficiency Factors for Bark Substrates: Biostability, Aeration, or Phytotoxicity
R. Naasz, J. Caron, Jean Legault and André Pichette

Mini-Reviews in Organic Chemistry, Volume 6, Issue 4, Pages 321-344, 2009
Recent Progress in the Synthesis of Naturally Occurring Triterpenoid Saponins
Charles Gauthier, Jean Legault, André Pichette

Bioorganic and Medicinal Chemistry Letters. 2009 Apr 15;19(8):2310-4. Epub 2009 Feb 23. SD PM
Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products.
Charles Gauthier, Jean Legault, Marianne Piochon, Serge Lavoie, Tremblay S, André Pichette.

Tetrahedron Letters, Volume 50, Issue 9, Pages 988-991, 4 March 2009. SD
Synthesis of betulinic acid acyl glucuronide for application in anticancer prodrug monotherapy
Charles Gauthier, Jean Legault, Simon Rondeau, André Pichette

Bioorganic and Medicinal Chemistry. 2009 Mar 1;17(5):2002-8. Epub 2009 Jan 15. SD PM
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
Charles Gauthier, Jean Legault, Karl Girard-Lalancette, Vakhtang Mshvildadze, André Pichette.

Phytochemistry. 2009 Jan;70(2):228-36. Epub 2009 Jan 10. SD PM
Synthesis and cytotoxicity evaluation of natural alpha-bisabolol beta-D-fucopyranoside and analogues.
Marianne Piochon, Jean Legault, Charles Gauthier, André Pichette.

Tetrahedron, Volume 64, Issues 30-31, Pages 7386-7399, 21 July 2008. SD
Synthesis of two natural betulinic acid saponins containing a-l-rhamnopyranosyl-(1->2)-a-l-arabinopyranose and their analogues
Charles Gauthier, Jean Legault, Serge Lavoie, Simon Rondeau, Samuel Tremblay, André Pichette

Journal of Natural Products. 2009 Jan;72(1):72-81. PM
Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins.
Charles Gauthier, Jean Legault, Serge Lavoie, Rondeau S, Tremblay S, André Pichette.

Molecules. 2008 Nov 26;13(12):2925-34. PM
Cytotoxic steroidal saponins from the flowers of Allium leucanthum.
Lasha Mskhiladze, Jean Legault, Serge Lavoie, Vakhtang Mshvildadze, Jumber Kuchukhidze, Riad Elias, André Pichette.
Texte intégral gratuit

Phytotherapy Research. 2008 Jul;22(7):919-22. PM WS
Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa.
François Simard, Jean Legault, Serge Lavoie, Vakhtang Mshvildadze, André Pichette.

Chemical and Pharmaceutical Bulletin (Tokyo). 2008 Jan;56(1):82-4. PM
A new labdane diterpene from the flowers of Solidago canadensis.
Marie-Eve Bradette-Hébert, Jean Legault, Serge Lavoie, André Pichette.
Texte intégral gratuit

Tetrahedron Letters, Volume 48, Issue 48, Pages 8416-8419, 26 November 2007 SD
Useful approach to access germanicanes from betulin
Dominic Thibeault, Jean Legault, Jimmy Bouchard, André Pichette

Journal of Pharmacy and Pharmacology. 2007 Dec;59(12):1643-7. PM
Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel.
Jean Legault, André Pichette.

Bioorganic and Medicinal Chemistry. 2007 Sep 15;15(18):6144-57. Epub 2007 Jun 20. SD PM
Synthesis and structure-activity relationship study of cytotoxic germanicane- and lupane-type 3beta-O-monodesmosidic saponins starting from betulin.
Dominic Thibeault, Charles Gauthier, Jean Legault, Jimmy Bouchard, Philippe Dufour, André Pichette.

Phytochemistry. 2007 Oct;68(20):2531-6. Epub 2007 Jun 27. SD PM
Anticancer diarylheptanoid glycosides from the inner bark of Betula papyrifera.
Vakhtang Mshvildadze, Jean Legault, Serge Lavoie, Charles Gauthier, André Pichette.

Phytotherapy Research. 2007 Jun;21(6):536-40. PM
Composition and cytotoxic activity of the leaf essential oil of Comptonia peregrina (L.) Coulter.
Muriel Sylvestre, André Pichette, Serge Lavoie, Angélique Longtin, Jean Legault.

Journal of Ethnopharmacology. 2007 Apr 20;111(1):22-8. Epub 2006 Oct 26. SD PM
Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius.
Dominic Dufour, André Pichette, Vakhtang Mshvildadze, Marie-Eve Bradette-Hébert, Serge Lavoie, Angélique Longtin, Catherine Laprise, Jean Legault.

Food Chemistry, Volume 104, Issue 3, Pages 1040-1047, 2007. SD
Quantification of phenolic contents and antioxidant capacity of Atlantic sea cucumber (Cucumaria frondosa)
Jean Mamelona, Émilien Pelletier, Karl Girard-Lalancette, Jean Legault, Salwa Karboune, Selim Kermasha

Chemistry of Natural Compounds, Volume 43, Issue 3, Pages 361-362, Published: May 2007.
Cyclocephalogenin and cyclogalegigenin from Astragalus caucasicus
MD Alaniya, TI Gigoshvili, NS Kavtaradze, Serge Lavoie, André Pichette, VD Mshvildadze

Natural Product Communications, Volume 2, Issue 12, Pages 1269-1272, Published: 2007.
Chemical composition of leaf essential oil of Hedyosmum arborescens and evaluation of its anticancer activity
Muriel Sylvestre, André Pichette, Agélique Longtin, Marie-Anna Coupp De Ker Martin, Sylvie Rodin Bercion, Jean Legault

Chemistry of Natural Compounds, Volume 43, Issue 6, Pages 758-759, Published: Nov 2007.
Cyclocanthoside E from Astragalus caucasicus
MD Alaniya, NS Kavtaradze, TI Gigoshvili, Serge Lavoie, André Pichette, VV Mshvildadze

Chemistry of Natural Compounds, Volume 43, Issue 6, Pages 706-707, Published: NOV 2007.
Coniferyl alcohol glucoside from Astragalus bungeanus
MD Alaniya, NS Kavtaradze, V Mshvildadze, Serge Lavoie, André Pichette

Natural Product Communications, Volume 2, Issue 12, Pages 1273-1276, Published 2007.
Volatile leaf constituents and anticancer activity of Bursera simaruba (L.) Sarg. essential oil
Muriel Sylvestre, Angélique Longtin, Andre Pichette, Jean Legault

Chemical and Pharmaceutical Bulletin (Tokyo). 2006 Oct;54(10):1429-32. PM
New labdane diterpenes from the stem bark of Larix laricina.
André Pichette, Serge Lavoie, Pierre Morin, Vakhtang Mshvildadze, Maxime Lebrun, Jean Legault.
Texte intégral gratuit

Bioorganic and Medicinal Chemistry. 2006 Oct 1;14(19):6713-25. Epub 2006 Jun 19. SD PM
Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents.
Charles Gauthier, Jean Legault, Maxime Lebrun, Philippe Dufour, André Pichette.

Phytotherapy Research. 2006 May;20(5):371-3. PM
Composition and antibacterial activity of Abies balsamea essential oil.
André Pichette, Pierre-Luc Larouche, Maxime Lebrun, Jean Legault.

Journal of Ethnopharmacology. 2006 Jan 3;103(1):99-102. Epub 2005 Sep 15. SD PM
Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe.
Muriel Sylvestre, André Pichette, Angélique Longtin, Francine Nagau, Jean Legault.

Journal of Essential Oil Research, Volume 18, Issue 1, Pages 38-41, Published Jan-Feb 2006.
Investigation of leaf essential oil of Myrica gale L. from Quebec: Purification and analysis of oxygenated fractions
Muriel Sylvestre, Jean Legault, Serge Lavoie, André Pichette

Phytomedicine. 2005 Apr;12(4):299-304. PM
Chemical composition and anticancer activity of leaf essential oil of Myrica gale L.
Muriel Sylvestre, Jean Legault, Dominic Dufour, André Pichette.

Planta Medica. 2003 May;69(5):402-7. PM
Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action.
Jean Legault, Dahl W, Debiton E, André Pichette, Madelmont JC.

Thermochimica Acta, Volume 398, Issues 1-2, Pages 153-166, 5 March 2003 SD
Betulin isolation from birch bark by vacuum and atmospheric sublimation. A thermogravimetric study
Marie-France Guidoin, Jin Yang, André Pichette, Christian Roy